
Treatment resistance in diffuse large
Lieven
- 0
Therapy resistance in diffuse massive B-cell lymphoma
Diffuse massive B-cell lymphoma (DLBCL) is a extremely heterogeneous illness and represents the most typical subtype of lymphoma. Though 60-70% of all sufferers will be cured by the present normal of care within the frontline setting, nearly all of the remaining sufferers will expertise remedy resistance and have a poor medical consequence. Quite a few efforts have been made to enhance the efficacy of the usual routine by, for instance, dose intensification or including novel brokers. Nevertheless, these outcomes typically did not exhibit important medical advantages.
Therefore, understanding remedy resistance is a urgent have to optimize the end result of these sufferers. On this Evaluate, we first describe the conceptual sources of remedy resistance in DLBCL after which present detailed and up-to-date molecular perception into the mechanisms of resistance to the present remedy choices in DLBCL. We lastly spotlight the potential methods for rationally managing remedy resistance from each the preventive and interventional views.

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FRA9D Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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LV703719 | ABM | 1.0 ug DNA | EUR 540 |
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Resistant hyponatraemia in a affected person with follicular lymphoma and coronary heart failure with decreased ejection fraction: a case report
Background: Hyponatraemia is a frequent drawback in sufferers with coronary heart failure. It may be tough to deal with, particularly within the presence of the affected person’s wants for diuresis and manipulation of the renin-angiotensin-aldosterone system (RAAS).
Case abstract: This issues a 74-year-old lady with follicular lymphoma and extreme world left ventricular systolic dysfunction secondary to remedy with R-CHOP chemotherapy. She offered a tough problem within the administration of her decompensated coronary heart failure alongside hyponatraemia as little as 113 mmol/L. This was resistant to plain remedy. The resistance to typical measures necessitated remedy with Tolvaptan, a selective arginine vasopressin V2 inhibitor used to deal with hyponatraemia in syndrome of inappropriate anti-diuretic hormone. This, together with a strict fluid restriction of 500 mL/day, resolved the affected person’s hyponatraemia and enabled her discharge house on tolerated coronary heart failure remedy. She has now remained steady for nearly 12 months.
Dialogue: The potential causes of hyponatraemia are mentioned together with the function of Tolvaptan in its administration.
Regional Mind Glucose Metabolism and Its Prognostic Worth in Pretreatment Extranodal Pure Killer/T-Cell Lymphoma Sufferers
Goal: To discover regional mind glucose metabolic abnormalities of pretreatment stage I/II extranodal pure killer/T-cell lymphoma (ENKTL) sufferers utilizing positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose built-in with computed tomography (18F-FDG PET/CT) and assess its prognostic worth.
Strategies: Sixty pretreatment stage I/II ENKTL sufferers have been enrolled on this retrospective examine and divided into survival (n = 45) and loss of life (n = 15) teams in response to their standing on the finish of follow-up. A management group consisted of 60 wholesome topics. Regional cerebral glucose metabolism was evaluated on a voxel-by-voxel foundation utilizing statistical parametric mapping (SPM8) underneath a sure significance stage (P < 0. 001) and voxel threshold (Ok = 100 voxels).
Outcomes: Decreased metabolism was famous in sufferers, involving the bilateral prefrontal and orbitofrontal cortex, partial parietal and occipital cortex, cingulate gyrus and cerebellum; the sensorimotor cortex was largely spared. Elevated metabolism was noticed within the bilateral putamen, amygdala, and parahippocampal gyrus. In contrast with the survival group, the loss of life group had greater metabolism within the bilateral amygdala, putamen, left thalamus, uncus, and parahippocampal gyrus. Solely B signs have been related to the elevated metabolism of basal ganglia and thalamus (BGT). Sufferers with excessive metabolic tumor quantity, complete lesion glycolysis (TLG) and BGT metabolism had a poor prognosis. TLG and most standardized uptake worth (SUVmax) LBGT/SUVmaxRight cerebellum have been related to Jap Cooperative Oncology Group (ECOG) and prognostic index of pure killer lymphoma and Epstein-Barr virus-DNA (PINKE) scores. In multivariate evaluation, solely ECOG was an unbiased prognostic issue of each progression-free survival (PFS) and total survival (OS). PINKE was an unbiased prognostic issue of OS.
Conclusion: Pretreatment stage I/II ENKTL sufferers exhibited irregular regional cerebral glucose metabolism. Greater pretreatment glucose metabolism in BGT might predict a comparatively poor prognosis however didn’t surpass the predictive values of ECOG and PINKE in stage I/II ENKTL sufferers.
Prognosis and Individualized Therapy of Secondary Central Nervous System Lymphoma: A Case Report
Non-Hodgkin lymphoma can disseminate to the central nervous system at initiation of remedy for systemic lymphoma or unfold in the course of the relapse of systematic lymphoma with CNS involvement, which is outlined as secondary central nervous system lymphoma (SCNSL). The incidence of SCNSL relies on the pathological sort of lymphoma and is very excessive in aggressive lymphoma. SCNSL has a poor prognosis due to the shortage of efficient remedy regimens.
This text presents a uncommon case of SCNSL; an individualized remedy routine was designed in response to the genetic analyses of the affected person tumor and included a Bruton’s tyrosine kinase (BTK) inhibitor. After six cycles of remedy and one other two cycles of rituximab, most lesions misplaced their metabolic exercise. Nevertheless, within the last stage of remedy, our affected person sadly suffered from respiratory failure, which revealed that we must always pay consideration to Pneumocystis jirovecii pneumonia throughout ibrutinib remedy.
The medical potential of circulating immune cell counts in major gastric lymphoma
Background: Excessive neutrophil-lymphocyte ratio (NLR) is linked to poor total survival (OS) in gastrointestinal tract cancers. This examine explores the medical worth of NLR, along with absolute lymphocyte rely (ALC) and different hematologic parameters in affiliation with distant metastases and OS in major gastric lymphoma (PGL) sufferers.
Strategies: Scientific information of 139 PGL sufferers who acquired remedy at King Hussein Most cancers Middle (KHCC), Amman-Jordan have been retrospectively evaluated. Utilizing information from full blood rely (CBC) exams, the next hematologic parameters: absolute neutrophil rely (ANC), ALC, absolute eosinophil rely (AEC), absolute monocyte rely (AMC), NLR, platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) have been assessed in affiliation with the next medical outcomes: presence or absence of baseline distant metastases and OS. We carried out univariate and multivariate analyses assessing the varied hematologic parameters in affiliation with distant metastases.
Outcomes: Univariate and multivariate analyses indicated that sufferers with an elevated NLR (>3.14) displayed extra baseline distant metastases in comparison with sufferers with a low NLR (≤3.14), (P worth: 0.02 and 0.018, respectively). Excessive baseline ALC (>1,819/µL) was related to decrease baseline distant metastases (P worth: 0.04). Within the OS evaluation, excessive baseline ANC (>5,100/µL), NLR (>2.75), and PLR (>0.16) have been related to poor OS, (P worth: 0.027, 0.016, and 0.011 respectively).
Conclusions: Excessive NLR and ALC have been related to baseline distant metastases. Excessive baseline ANC, NLR, and PLR have been related to poor OS. Hematologic parameters could be probably useful in assessing and correlating NLR with the response success to remedy in PGL.
FRA11D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725974 | ABM | 1.0 ug DNA | Ask for price |
FRA11E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725980 | ABM | 1.0 ug DNA | Ask for price |
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LV725992 | ABM | 1.0 ug DNA | Ask for price |
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LV725998 | ABM | 1.0 ug DNA | Ask for price |
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LV726004 | ABM | 1.0 ug DNA | Ask for price |
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LV726070 | ABM | 1.0 ug DNA | Ask for price |
FRA15A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726076 | ABM | 1.0 ug DNA | Ask for price |
FRA16A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726082 | ABM | 1.0 ug DNA | Ask for price |
FRA16B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726088 | ABM | 1.0 ug DNA | Ask for price |
FRA16C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726094 | ABM | 1.0 ug DNA | Ask for price |
FRA16D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726100 | ABM | 1.0 ug DNA | Ask for price |
FRA16E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726106 | ABM | 1.0 ug DNA | Ask for price |
FRA17A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726112 | ABM | 1.0 ug DNA | Ask for price |
FRA17B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726118 | ABM | 1.0 ug DNA | Ask for price |
FRA18A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726124 | ABM | 1.0 ug DNA | Ask for price |
FRA18B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726130 | ABM | 1.0 ug DNA | Ask for price |
FRA18C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726136 | ABM | 1.0 ug DNA | Ask for price |
FRA19A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726142 | ABM | 1.0 ug DNA | Ask for price |
FRA19B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726148 | ABM | 1.0 ug DNA | Ask for price |
FRA20A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726154 | ABM | 1.0 ug DNA | Ask for price |
FRA20B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726160 | ABM | 1.0 ug DNA | Ask for price |
FRA22A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726166 | ABM | 1.0 ug DNA | Ask for price |
FRA22B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV726172 | ABM | 1.0 ug DNA | Ask for price |
FRA1A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725512 | ABM | 1.0 ug DNA | Ask for price |
FRA1B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725518 | ABM | 1.0 ug DNA | Ask for price |
FRA1C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725524 | ABM | 1.0 ug DNA | Ask for price |
FRA1D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725530 | ABM | 1.0 ug DNA | Ask for price |
FRA1E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725536 | ABM | 1.0 ug DNA | Ask for price |
FRA1F Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725542 | ABM | 1.0 ug DNA | Ask for price |
FRA1G Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725548 | ABM | 1.0 ug DNA | Ask for price |
FRA1H Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725554 | ABM | 1.0 ug DNA | Ask for price |
FRA1I Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725560 | ABM | 1.0 ug DNA | Ask for price |
FRA1J Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725566 | ABM | 1.0 ug DNA | Ask for price |
FRA1K Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725572 | ABM | 1.0 ug DNA | Ask for price |
FRA1L Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725578 | ABM | 1.0 ug DNA | Ask for price |
FRA1M Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725584 | ABM | 1.0 ug DNA | Ask for price |
FRA2A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725590 | ABM | 1.0 ug DNA | Ask for price |
FRA2B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725596 | ABM | 1.0 ug DNA | Ask for price |
FRA2C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725602 | ABM | 1.0 ug DNA | Ask for price |
FRA2D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725608 | ABM | 1.0 ug DNA | Ask for price |
FRA2E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725614 | ABM | 1.0 ug DNA | Ask for price |
FRA2F Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725620 | ABM | 1.0 ug DNA | Ask for price |
FRA2G Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725626 | ABM | 1.0 ug DNA | Ask for price |
FRA2H Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725632 | ABM | 1.0 ug DNA | Ask for price |
FRA2I Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725638 | ABM | 1.0 ug DNA | Ask for price |
FRA2J Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725644 | ABM | 1.0 ug DNA | Ask for price |
FRA2K Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725650 | ABM | 1.0 ug DNA | Ask for price |
FRA3A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725656 | ABM | 1.0 ug DNA | Ask for price |
FRA3B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725662 | ABM | 1.0 ug DNA | Ask for price |
FRA3C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725668 | ABM | 1.0 ug DNA | Ask for price |
FRA3D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725674 | ABM | 1.0 ug DNA | Ask for price |
FRA4A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725680 | ABM | 1.0 ug DNA | Ask for price |
FRA4B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725686 | ABM | 1.0 ug DNA | Ask for price |
FRA4C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725692 | ABM | 1.0 ug DNA | Ask for price |
FRA4D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725698 | ABM | 1.0 ug DNA | Ask for price |
FRA5A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725704 | ABM | 1.0 ug DNA | Ask for price |
FRA5B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725710 | ABM | 1.0 ug DNA | Ask for price |
FRA5C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725716 | ABM | 1.0 ug DNA | Ask for price |
FRA5D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725722 | ABM | 1.0 ug DNA | Ask for price |
FRA5E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725728 | ABM | 1.0 ug DNA | Ask for price |
FRA5F Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725734 | ABM | 1.0 ug DNA | Ask for price |
FRA5G Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725740 | ABM | 1.0 ug DNA | Ask for price |
FRA6A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725746 | ABM | 1.0 ug DNA | Ask for price |
FRA6B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725752 | ABM | 1.0 ug DNA | Ask for price |
FRA6C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725758 | ABM | 1.0 ug DNA | Ask for price |
FRA6D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725764 | ABM | 1.0 ug DNA | Ask for price |
FRA6E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725770 | ABM | 1.0 ug DNA | Ask for price |
FRA6F Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725776 | ABM | 1.0 ug DNA | Ask for price |
FRA6G Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725782 | ABM | 1.0 ug DNA | Ask for price |
FRA7A Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725788 | ABM | 1.0 ug DNA | Ask for price |
FRA7B Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725794 | ABM | 1.0 ug DNA | Ask for price |
FRA7C Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725800 | ABM | 1.0 ug DNA | Ask for price |
FRA7D Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725806 | ABM | 1.0 ug DNA | Ask for price |
FRA7E Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725812 | ABM | 1.0 ug DNA | Ask for price |
FRA7F Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725818 | ABM | 1.0 ug DNA | Ask for price |
FRA7G Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725824 | ABM | 1.0 ug DNA | Ask for price |
FRA7H Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725830 | ABM | 1.0 ug DNA | Ask for price |
FRA7I Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725836 | ABM | 1.0 ug DNA | Ask for price |
FRA7J Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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LV725842 | ABM | 1.0 ug DNA | Ask for price |